6 doctors weighed in:

Can you tell me what are contraindications of herceptin (trastuzumab)?

6 doctors weighed in
Dr. Paul Harper
Surgery
3 doctors agree

In brief: None except...

There are no contraindications to this medication but it should not be used in pregnant women because of possible harm to the baby.

In brief: None except...

There are no contraindications to this medication but it should not be used in pregnant women because of possible harm to the baby.
Dr. Paul Harper
Dr. Paul Harper
Thank
Dr. Pedro Hernandez
Internal Medicine - Geriatrics
2 doctors agree

In brief: Absolute?: no

The decision to prescribe one medicine is based in that the benefit is expected to outweight the side effects.
This drug may cause or worsen cardiomyopathy and or lung disease. To take this medicine may be life saving for you. Discuss the pro and cons with your oncologist. Review the drug with the manufacturer online site or ask your oncologist. Avoid in pregnancy.

In brief: Absolute?: no

The decision to prescribe one medicine is based in that the benefit is expected to outweight the side effects.
This drug may cause or worsen cardiomyopathy and or lung disease. To take this medicine may be life saving for you. Discuss the pro and cons with your oncologist. Review the drug with the manufacturer online site or ask your oncologist. Avoid in pregnancy.
Dr. Pedro Hernandez
Dr. Pedro Hernandez
Thank
1 comment
Dr. Paul Harper
I agree that there are serious potential side effects with the use of herceptain, some of which are quite serious such as cardiomyopathy. However the question asked about contraindications, not complications. The only caution (or contraindication if you prefer) is pregnancy. And in THAT case the literature states we do not know what the effect on the fetus will be.
Dr. Devon Webster
Internal Medicine - Oncology
1 doctor agrees

In brief: Heart failure

You can't have significant heart failure and receive herceptin (trastuzumab).
Herceptin (trastuzumab) can decrease the pumping strength of the heart. Some patients who have had chemotherapy in the past have lost heart function, and as a result should not receive herceptin (trastuzumab). A left ventricular ejection fraction of less than 40% is a contraindication. An allergy to Herceptin (trastuzumab) is also a contraindication.

In brief: Heart failure

You can't have significant heart failure and receive herceptin (trastuzumab).
Herceptin (trastuzumab) can decrease the pumping strength of the heart. Some patients who have had chemotherapy in the past have lost heart function, and as a result should not receive herceptin (trastuzumab). A left ventricular ejection fraction of less than 40% is a contraindication. An allergy to Herceptin (trastuzumab) is also a contraindication.
Dr. Devon Webster
Dr. Devon Webster
Thank
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