8 doctors weighed in:
Why would a splenectomy increase the number of platelets in my blood?
8 doctors weighed in

Dr. Matt Malkin
Anesthesiology
3 doctors agree
In brief: Spleen function
The spleen filters blood and pulls dead cells from circulation.
In itp and other hypersplenic illnesses, too many platelets are pulled out of circulation. Removing the spleen allows more to stay circulating. You will need vaccines against certain organisms that the spleen protects you from.

In brief: Spleen function
The spleen filters blood and pulls dead cells from circulation.
In itp and other hypersplenic illnesses, too many platelets are pulled out of circulation. Removing the spleen allows more to stay circulating. You will need vaccines against certain organisms that the spleen protects you from.
Dr. Matt Malkin
Dr. Matt Malkin
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Dr. Michael Engel
Pediatrics - Hematology & Oncology
2 doctors agree
In brief: I'd also add....
That splenectomy does not always correct the platelet count in patients with itp.
The spleen has large numbers of macrophages, which recognize opsonized platelets and clear them from the blood stream. However, virtually all tissues contain macrophages (that go by other names...Eg., kupfer cells in the liver) and they too can phagocytize opsonized platelets. Approx 80% of pts respond to splenectomy.

In brief: I'd also add....
That splenectomy does not always correct the platelet count in patients with itp.
The spleen has large numbers of macrophages, which recognize opsonized platelets and clear them from the blood stream. However, virtually all tissues contain macrophages (that go by other names...Eg., kupfer cells in the liver) and they too can phagocytize opsonized platelets. Approx 80% of pts respond to splenectomy.
Dr. Michael Engel
Dr. Michael Engel
Thank
Dr. Barry Rosen
Surgery
2 doctors agree
In brief: Filter Removal
One of the jobs of the spleen is to filter old or damaged blood cells and platelets from the bloodstream. The most common reason to perform a splenectomy, except for traumatic injuries, is itp, a condition where the body makes antibodies that attack the bodies platelets.
If the spleen is removed, the damaged platelets are not removed from the bloodstream and can continue to function normally.

In brief: Filter Removal
One of the jobs of the spleen is to filter old or damaged blood cells and platelets from the bloodstream. The most common reason to perform a splenectomy, except for traumatic injuries, is itp, a condition where the body makes antibodies that attack the bodies platelets.
If the spleen is removed, the damaged platelets are not removed from the bloodstream and can continue to function normally.
Dr. Barry Rosen
Dr. Barry Rosen
Thank
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