Adopt clean lifestyl. A splenectomy may be required due to multiple types of underlying disease states, preparation should be centered around your underlying disease. As the spleen functions as a filter, helping minimize infection, you may be more susceptible to infection. Flu shots should become routine, especially in the elderly. Avoid contact with those who are ill from infection.
Vaccination. You should be vaccinated against 3 bacteria. Ask your surgeon/ pcp about them. They need to be given around 3 weeks before to get the benefit.