Can you take seroquel (quetiapine) with flexeril?

Ask your doctor. Many drugs have interactions with each other and that includes this combination. Both of these meds. Have a "sedative" like effect and the combination is at minimum additive. If you have been on one medication for some time than the second will likely be less prone to cause an issue than were you to start both at the same time. This is an issue that a professional should be actively managing.

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