Can drinking caffeine make the spleen enlarged?

Caffeine/Spleen. Not likely. Explore other possible causes such as blood disease or liver problems.
No. If your spleen is enlarged, there is some other cause. The most common causes of splenic enlargement are leukemias and lymphomas, cirrhosis of the liver which causes the spleen to enlarge because blood backs up in the portal vein with increasing pressure, and enlarges the spleen. There are a number of poorly understood blood disorders like itp and ttp that also can enlarge the spleen.