After a splenectomy, will I need to take any special medications?

Yes. You will need to be immunized against encapsulated bacteria. The three vaccines you should get are against strep pneumonia (pneumovax), hemophilus influenza (not the flu vaccine), and neisseria meningitidis. If your spleen was taken out electively, you should have gotten the vaccines before surgery. You should get these at least every five years.