How is breast cancer passed down in families?

Familial breast ca. 2 genes are commmonly tested for called brca1 & 2. They are inherited from either male or female lines [not sex-linked], meaning history of breast cancer from both mom & dad's side are important.
Depends.. There are currently two known genes that cause breast cancer called brca1 and brca2. These genes are inherited in an autosomal dominant manner, meaning that if one of your parents has the gene you would have a 50% chance of having it as well. There are also most likely many other genes that cause breast cancer that have not yet been identified. Know you risk and speak to your doctor.

Related Questions

Should I have genetic testing for breast cancer if family history?

Maybe. If in doubt go to a genetics counselor - most cancer centers have one. The consultation is not expensive, but the test itself is. They will ask about your age, the exact numbers of family members affected, their age at diagnosis, whether one or both breasts, their relationship to you (mother, sister, or daughter increase your personal risk), other cancers in the family. Then they can advise you. Read more...
Perhaps. The risk factor/indications for genetic testing are: multiple family members with a history of breast cancer, bilateral breast cancer, male breast cancer, ovarian cancer, ashkenazi jewish heritage, young age of diagnosis (<50 but really premenopausal particular early 40s-30s), triple negative (er/pr/her2-) status and age <60. Read more...

Should I get a genetic test if breast cancer runs in my family in aunts and cousins?

Test them first. In general, we look most closely at first-degree relatives (mom, sister, daughter), but it is still pertinent, especially if they are young. It is always best to have the members of your family who have had breast cancer get the brca test first. If they are brca(+), you can get tested for that specific mutation at a much lower cost; if they are(-), your family can feel comfortable about their risks. Read more...
Depends. First find a genetic counselor or a high risk breast specialist. They can assess your risk. A lot depends on the number of second order relatives, their ages at diagnosis, whether any were bilateral - and any other cancers in your family -especially ovarian, colon, or uterine. The office visit is not too expensive, but the actual test is. Read more...
Genetic testing. Perhaps, yes. But, before you do the test, you should have a detail discussion re - what is your risk for certain cancers-, what kind of genetic testing needed, how to interprete the result , what the consequencies of the test are etc- those above are things you should discuss either wih your oncologist or with a genetic counsellor. Discuss with your oncologist in detail. Read more...

I have breast cancer in my family. Should I choose the most aggressive treatment? Should I have surgery to remove my healthy breast to keep from getting breast cancer in it? Should I have genetic testing?

Depends. Talk to your physician or a genetic counselor to decide if your family history suggests you have a > 10% chance of carrying a breast cancer gene. If so, you should be tested. The results may help guide you as to how aggressive you should be with the management of your breasts and your ovaries. Read more...
Take your time. One of the most difficult situations my breast cancer patients face is when they are diagnosed with a cancer that could otherwise be treated by lumpectomy, but a strong family history warrants consideration of double mastectomy. If this decision does not come easily to you, i suggest having the lumpectomy and stage the cancer; if chemo is needed, you will have months to decide re: double mast-x. Read more...
Consider all options. Take a deep breath. You have time to decide these things. If your mother, sister, or daughter had breast cancer, you have a higher risk of having a brca mutation. See a genetic counselor. If genetic testing is recommended, do that right away. Those results will help you make decisions about surgery and chemotherapy. My best advice: don't make decisions based on fear! Read more...
Difficult decisions. Being faced with a new cancer diagnosis can be overwhelming. Pts are presented with lots of info and difficult options to consider. There are medical recs physicians can make but peace of mind on the pt's part plays an important role too. Most importantly, focus on optimum treatment for the cancer that has been diagnosed. Preventing something that may (or more likely won't) later occur is 2nd. Read more...
Maybe, maybe, yes. Hi, as a doc who had triple negative breat cancer, I am a bit less independent with my thinking. We don't know that much about breast cancer. Get more than one opinion.Do you have a breast cancer diagnosis? Brca i and ii are genetic tests that can be done to indicate the likehood of certain types of breast cancer, but these tests are not perfect indicators. Consider genetic tesing. Read more...

36 year-old woman whose mother was diagnosed with breast cancer at age 34 and a PALB2 mutation wonders if mastectomy is needed to lower her risk.....?

You need testing. If your mother was a BRCA carrier then it is important that you get tested. Since you know that she has a PLAB2 mutation then your testing can even be more precise. If you are a carrier then see an experienced breast surgeon. They can calculate your lifetime risk as well as your 5 year risk to help you make your decisions regarding mastectomy and ovary removal. Read more...
You are doing fine. You are already under good supervision which includes proper genetic counseling in terms of future testing or any active intervention. Annual breast physical examination along with annual MRI of both breasts to screen for early breast cancer would be adequate in my view. I do not recommend risk reduction mastectomy except in folks with BRCA mutation. You should complete your family(have children, if desired, before the age of 40 years). Read more...
Higher risk but not like BRCA. I am glad that you are seeing a GC as this area is evolving rapidly. PALB2 is a high-risk mutation but its risk is dependent on your family history and age. Your risk of lifetime breast cancer will be significantly higher than the average population (estimated 30-35% versus 12%). This is less than BRCA which is as high as 60-80%. Thus, bilateral mastectomy is a choice and not as strongly rec for PALB2. Surveillance should follow high-risk guidelines including MRI. Read more...
Close supervision. www.Breastcancer.org http://www.nejm.org/doi/full/10.1056/NEJMoa1400382?query=featured_home& By age 50 y/o 14 % of women with PALB2 mutation will have been diagnosed with, not died of, breast cancer, by 70 y/o that number is 35 %. A 34 y/o today is 14 and 36 years, respectively, away from those targets. We will have better diagnostic tools and better treatment by then. No data exists, whether women with prophylactic mastectomy do better. Advice: Close observation with MRI (not mammogram: radiation) and ideally follow up at a cancer center that takes care of other women with PALB2 mutation. Read more...
Is an option. This is a complicated issue and personal choice. There should be a percentage risk that you'd develop cancer and that would help to direct you. If it's, say, 80%, I would seriously consider removal. The options really include bilateral mastectomy vs. close surveillance, which should include MRI of the breast, breast exams and mammograms on more frequent basis than yearly, which it seems you're doing now. Read more...
Woud Work. With a mutation and a family history of breast cancer, having a bilateral prophylactic mastectomy would definitely lower the risk. The big question is how much risk would it lower and is it NEEDED? The needed is a question you will have to answer after you have discussed it and all your risks with your surgeon. Definitely would decrease the risk, but without full history, hard to say is needed. Read more...
Breast cancer. . This a complex question that is more appropriate for a direct face to face discussion. There are a number options that are valid. But for starters you need to get tested. . Read more...
Stop all medications. sorry that you have unusual unknown forms of metabolic, immune genetic defect No-one knows too much of it you can only save yourself by cut out all the meds. " If u don't take, you don't die--then don't take" especially the nutritional supplements like vitamin E, omega3 etc and immune suppressants they feed cancer cells before feed regular cells must have very healthy life style and don't respond to stress, stay happy do breast self exam and MRI instead X-ray worthless good luck. Read more...
It depends. The genetic councilor should be able to tell the chance of you having breast cancer in the future based on your entire family tree and the exact type of mutation. It would probably be around 40-60%. Higher screening is an acceptable option if you can get it regularly enough and be aggressive as soon as it is found. It is a difficult decision to make. There is also, anti-hormonal therapy that would reduce your risk of breast cancer. I would make the decision based on your lifestyle an access to healthcare. If you can have adequate and reliable follow ups then may be do that. If you are too nervous about it, then have the mastectomy. It is a difficult decision to make and needs to be tailored to you personally. Read more...
No! Although the PALB2 mutation increases risk, preventive mastectomy is not recommended. There are other ways to decrease your risk including taking raloxifene or tamoxifen. See a medical oncologist to discuss this (and a genetic counselor! ) Read more...

I need your expertise, is breast cancer genetic?

Genetics can play a. Significant role for some women (not for others). Include: being female, increasing age, genetics, family history of breast cancer, previous breast cancer, being caucasian, dense breast tissue, some previous benign breast conditions, never having given birth or 1st child after age 30, early menarche, late menopause, radiation (chest), exposure to diethylstilbestrol, hormone replacement after >>. Read more...

What is the genetic recurrence of breast cancer?

10-15% Hereditary. We believe that only 10-15% of breast cancers are hereditary, with the rest being environmental in origin. People w/the hereditary form of breast cancer tend to get diagnosed earlier in life and may get cancer in both breasts. When treated by lumpectomy or (single) mastectomy, it is not uncommon to develop a second, unrelated breast cancer; therefore, many opt for double mastectomies. Read more...

What is the benefit of getting genetic breast cancer testing?

Knowledge is Power. The brca test is a simple (tho, very expensive) blood test to determine if one carries the risk of developing the hereditary form of breast (& ovarian) cancer. Affected people have a 50%chance of passing this on to their children. If the test is (-), this can be very reassuring; if (+), one may choose to be proactive and undergo prophylactic (preventive) mastectomies and oophorectomies. Read more...
Genetic Testing . About 5 % of breast cancer patients may have brca 1 or brca 2. It is very important for patients who are positive for brca 1 or 2 who will be recommended to have resection of both breast and her ovarian also about 25% of breast cancer patients may have her 2 neu. Cellular receptor is human epidermal growth factor receptor 2 (her2/neu); its presence correlates with a poorer prognosis. The excellent. Read more...
For patient & family. It will be useful for both patient and her children if a patient with breast cancer is + for brca 1/2 mutation- she also has sgnificant risk to develop ovarian cancer so prophylactic surgery would be recommended. Other consequences for the family- the mutation can be inherited to the children-and if it's +, screening mammogram & MRI should be done earlier & prophylactic surgery'll be recommended. Read more...