7 doctors weighed in:

Do brca1 and brca2 mutations affect men the same way they affect women?

7 doctors weighed in
Dr. Barry Rosen
Surgery
4 doctors agree

In brief: No

The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation.
Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less.

In brief: No

The penetrance of a mutation defines the risk of developing the disease in those that carry a particular mutation.
Women with brca mutations have lifetime risks estimated between 40-80%; men's risks are much less-studied but are probably in the range of 10% or less.
Dr. Barry Rosen
Dr. Barry Rosen
Thank
Dr. Steven Rottman
Surgery - Plastics
1 doctor agrees

In brief: Male breast cancer

Men with a brca mutation have a dramatically elevated relative risk of developing breast cancer, but because the overall incidence of breast cancer in men is so low, the absolute risk is equal to or lower than the risk for women without a brca mutation.
Approximately 1% to 2% of men with a brca1 mutation will develop breast cancer by age 70 and 6% of men with a brca2 mutation will develop cancer.

In brief: Male breast cancer

Men with a brca mutation have a dramatically elevated relative risk of developing breast cancer, but because the overall incidence of breast cancer in men is so low, the absolute risk is equal to or lower than the risk for women without a brca mutation.
Approximately 1% to 2% of men with a brca1 mutation will develop breast cancer by age 70 and 6% of men with a brca2 mutation will develop cancer.
Dr. Steven Rottman
Dr. Steven Rottman
Thank
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