If I have too much estrogen, or not enough progesterone, does that make me more susceptible to breast cancer?

High E2/Prog is NG. A high estrogen/progesterone ratio is a contributing factor to many medical and metabolic problems. Breast, ovarian, cervical cancer, pms. High e2/prog ratio will activate your parasympathetic nervous system and cause symptoms from excess vagal stimulation. Have your doctor check your e2 and prog during mid luteal phase of your menstrual cycle (day 18-21).
Breast cancer risk. Maybe: some breast cancers take up estrogen as a sort of growth hormone to encourage growth, so too much estrogen can speed growth of these cancers. There is a very small increase in breast cancer risk with estrogen only given postmenopausally for the symptoms. Relative increase in Progesterone only is associated with some breast disorders also but cancer risk is unclear.

Related Questions

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual. Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. Read more...

Are the risks of getting cancer (especially breast cancer) higher, if I am already on hormone treatment (estrogen and progestogen) at age 17?

Family practice . Tell us why you are on hormone replacement therapy. Did they remove both ovaries or are they nonfunctional. Not higher risk for breast cancer. Slightly higher risk for blood clots. Don't smoke and exercise regularly. Read more...
No. Hormone use as birth control is not felt to increase the risk of developing breast cancer. It is the use of hormone replacement after menopause that is the concern. Read more...

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen. Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. Read more...
Estrogen. Tamoxifen is an anti- estrogen in the breast, but can act like estrogen in other organs, notably the uterus. Women on tamoxifen, who have not had a hysterectomy, need to have a gyne keep a close eye on uterine health. Read more...
It's complicated. Tamoxifen is a selective estrogen receptor modulator which competes with estrogen to block this receptor on cancer (and other) cells. It does not suppress production of either estrogen or progesterone. Ironically, it is effective against breast cancer cells that harbor either the estrogen or Progesterone receptors (although, tumors that are estrogen rec. (-) and Progesterone rec.(+)are rare.). Read more...

How much estrogen gets into system using vaginal estrogen. Family history of breast cancer but not me.?

Varies. Per the med insert: Premarin (conjugated estrogens) Vaginal Cream should not be used if you have unusual vaginal bleeding, have or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients. This is due to significant absorption thru the vaginal mucosa which is dose dependent. Not the same risk for someone with family history only. Read more...

How do breast cancer anti estrogen pills work?

Starve tumor. Many tumors are fed by estrogen - the main female horomone. Anti-estrogen pills block the effects of estrogen (in a variety of different ways) and thereby starve the tumor from a vital growth factor. Even if you are postmenopausal (or even male) your body still produces estrogen in places like the adrenals and subcutaneous fat. Read more...
Aromatase inhibitor. An aromatase inhibitor blocks the conversion of testosterone like hormones in fat cells to the strong estrogen (estrone). Read more...

Does natural progesterone prevent breast cancer?

No. There is no evidence Progesterone of any type prevents breast cancer, "natural" Progesterone or not. If a woman has menses that only occur a few times a year, six or four or fewer, however, Progesterone or progesterone-like compounds can very definitely prevent endometrial hyperplasia (which can lead to uterine cancer), and should be used regularly to oppose continuous estrogen stimulation. Read more...
No. Progesterone has been implicated as the "bad guy" in combined hormone replacement therapy when it comes to breast cancer. Women taking estrogen + progesterone, natural or not, were at higher risk of developing breast cancer. Also, their breast cancers tended to be more aggressive. Progesterone also seems to increase the aggressiveness of other cancers. Natural Progesterone is not any safer. Read more...

What is estrogen receptor positive breast cancer?

Estrogen-SensitiveCA. Normal breast cells have estrogen receptors which are like locks that estrogen "keys" fit into. Many breast cancer cells also have these estrogen receptors, which is good for 2 reasons: (1)these cancers tend to be less aggressive (since they resemble normal breast cells), and; (2)"anti-estrogens" such as tamoxifen can be very effective chemotherapeutic agents for these cancers. Read more...
One with receptors. These are tumors with estrogen receptors on them. This makes them susceptable to some chemotherapeutic agents, like tamoxifen. Read more...

What is meant by having estrogen receptor positive breast cancer?

Hormone responsive. Er positive breast cancer means that the cancer expresses estrogen receptors. This is beneficial because we can hormonally manipulate this type of cancer with drugs like tamoxifen and Arimidex (anastrozole) which are antiestrogens. Read more...
ER+. Estrogen receptors are small proteins found on the surface of some cancer cells. A positive result means the proteins are present, a negative result means they are not present. Read more...
Feeds the cancer. Most breast cancers are estrogen receptor positive. The cancer cells have receptors that fit the estrogen molecule that a body produces. Think: a lock and key - when estrogen binds to the receptor the tumor cell is stimulated to grow and divide. Er+ tumors can be blocked by tamoxifen and Arimidex (anastrozole) (and others) that interfere with this pathway. Read more...