4 doctors weighed in:
Have there been any adverse interactions between femara (letrozole) and grapefuit?
4 doctors weighed in

Dr. Barry Rosen
Surgery
2 doctors agree
In brief: Indirectly
There is a substance in grapefruit that disables the enzyme responsible for metabolizing estrogen in our bodies; therefore, eating grapefruit may increase the body's levels of estrogen.
Femara (letrozole) is used to inhibit the production of estrogen in the body as a treatment for hormone-sensitive breast cancer. Therefore, eating grapefruit in these circumstances may counteract what you are treating.

In brief: Indirectly
There is a substance in grapefruit that disables the enzyme responsible for metabolizing estrogen in our bodies; therefore, eating grapefruit may increase the body's levels of estrogen.
Femara (letrozole) is used to inhibit the production of estrogen in the body as a treatment for hormone-sensitive breast cancer. Therefore, eating grapefruit in these circumstances may counteract what you are treating.
Dr. Barry Rosen
Dr. Barry Rosen
Thank
Dr. Ted King
Phlebology
1 doctor agrees
In brief: Theoretically
There is a substance in grapefruit that disables the enzyme responsible for breaking down estrogen in our bodies; therefore, eating grapefruit could increase estrogen levels in the body.
Femara (letrozole) is used to inhibit the production of estrogen in the body as a treatment for hormone-sensitive breast cancer. Therefore, eating grapefruit could work against what you are treating.

In brief: Theoretically
There is a substance in grapefruit that disables the enzyme responsible for breaking down estrogen in our bodies; therefore, eating grapefruit could increase estrogen levels in the body.
Femara (letrozole) is used to inhibit the production of estrogen in the body as a treatment for hormone-sensitive breast cancer. Therefore, eating grapefruit could work against what you are treating.
Dr. Ted King
Dr. Ted King
Thank
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