Does pr-negative breast cancer respond to tamoxifen?

It depends. Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective.
Yes if ER+. If the breast cancer is er +, tamoxifen will work- however it will not work if the cancer is er-, pr-.
ER? Response to tamoxifen depends on the er (estrogen receptor) status.

Related Questions

Is tamoxifen a must for er/pr negative menstruating woman for breast cancer treatment?

No. Actually, it's er/pr positive women who are potential candidates for tamoxifen. This is advised for women whose cancer stage mandates chemotherapy, sometimes combined with traditional IV chemotherapy. Furthermore, we often recommend tamoxifen to prevent the development of a second cancer is breast cancer survivors. Read more...
No. This and similar medicines are anti Estrogens that block the receptors. So if the patient has negative receptors there is little benefit from the medication. So it's not a must. Read more...

Does tamoxifen stop breast cancer from growing?

Yes. Tamoxifen is an antiestrogen that blocks the ability of breast cancer cells to use estrogen; therefore, it is only effective in hormone sensitive (estrogen receptor +) breast cancers. When taken for 5 years, tamoxifen has been shown to both stop the growth of cancer cells in breast cancer patients and to prevent the development of breast cancer in women that are at high risk. Read more...
Is Possible. Tamoxifen is used as a hormone therapy in the breast cancers that exhibit an estrogen hormone receptor. (er+ tumors). Read more...

Can tamoxifen stop the growth of breast cancer?

Sometimes, Depending on type of cancer, especially hormone receptor status. But it really depends on specific circumstances whether this drug, or any drug, is appropriate drug for you. So you need to ask your doctor for specific advice. Read more...

Are there any other alternatives to tamoxifen for breast cancer?

Sometimes. If you are taking tamoxifen for treatment of breast cancer and are post-menopausal, a class of drugs called aromatase inhibitors may be even more effective. If tamoxifen is being used for cancer prevention, Raloxifene (evista) is an effective alternative. Read more...
Aromatase inhibitor. Tamoxifen is used for women who are premenopausal and have an estrogen responsive tumor. Aromatase inhibitors are used for the same tumors in women who are in menopause. Read more...
Additional info. Also let me add additional alternatives if pre-menopausal 1) bilateral oophorectomy (surgical or radiation) 2) chemical oophorectomy (goserelin or gnrh agonist). If this were chosen your oncologist might recommend aromatase inhibitor therapy, although this is a controversial topic. Read more...

What could happen if someone took tamoxifen if they didn't have breast cancer?

Talk to your doctor. Tamoxifen has other indications aside from treatment of breast cancer such as reducing the risk of breast cancer in women who carry high risk for developing breast cancer. It has many side effects that need to be taken into consideration before taking this medicine. It needs to be prescribed by a health care provider who is familiar in its indications and side effects. Do not take it on your own. Read more...

I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

May surprise you but. ...Folks with high risk for breast cancer (without cancer) can take it to reduce their risk. It's not for everybody and should be done under the care of a specialist in the field. Anybody else will get the side effects (hot flashes and increased risk for blood clots and uterine cancer) for no gain at all. Read more...
A/W Dr Encarnacion. Tamoxifen may be appropriately used to reduce risk of breast cancer if there is an elevated Gail risk score (Breast Cancer Risk Assessment Tool -Gail Model) Read more...

Does tamoxifen help prevent breast cancer?

Yes. Tamoxifen use may reduce the development of breast cancer in high-risk patients by about 50%. There are risks associated with tamoxifen, so the decision whether to take this medication is based upon an individual patient's risk:benefit analysis. Read more...
Yes - ER+ breast CA. The p-1 trial showed in high risk women tamoxifen decreased the risk of er+ tumors by 40-50% (no difference in er- tumors) over palcebo. The p-2 or star trial compared tamoxifen to raloxifene/evista and saw similar overall benefits with some slight variations. Recently, a new trial has shown 65% reduction benefit for the aromatase inhibitor Exemestane over placebo. Read more...
Recurrence. It prevents recurrence in women with estrogen receptor positive tumors. Read more...
And new primaries. Tamoxifen blocks estrogen and Progesterone receptors which when stimulated can cause remnant cancer cells to be stimulated to grow back and also can cause normal cells to be overstimulated to develop into new hormonally sensitive cancer. Statistically it reduces the chance of recurrence by 30% and reduces the chance of a second primary by 50%. Read more...
Secondary Prevention. Tamoxifen also can be used to prevent breast cancer in the other breast as well as "secondary prevention" of breast cancer in patients who are at higher than normal risk of developing breast cancer. Read more...

When do breast cancer patients need tamoxifen?

Tamoxifen. A selective estrogen receptor modulator is effective added therapy for women with well-differentiated, estrogen receptor positive breast cancers. Read more...
Estrogen receptor +. Tamoxifen is only indicated for estrogen receptor positive breast cancers. Read more...