Does postmenopausal hormone therapy lead to breast cancer?

Very low Risk. With due respect. The landmark study, whi, is called into question in so many ways. The nih spent millions to answer very little. As an re, i feel there are many facets to HRT and a careful and comprehensive evaluation of the literature supports a very minimal at best increase in breast cancer and the evidence points to the progestin component only (provera). Consultation warranted.
Controversial. Hormone therapy can be estrogen only or combination estrogen &progesterone (ep). Almost all studies show an increase in breast ca in women who take ep. There may be more breast ca dx/'d in women who take e, but diagnosed earlier 7 more curable. Some type of Progesterone is indicated in women w/ a uterus to prevent uterine ca.
Yes, it can. While not every woman who takes hormone replacement therapy will get breast cancer, there is compelling evidence that it's use substantially increases the risk of breast cancer. A landmark study published last decade sponsored by the national cancer institute found a 25% increase in breast cancer in women who took estrogen and progestin.

Related Questions

Is it true that female hormone therapy can increase the risk of breast cancer?

Yes. Certain hormones, especially longer use of estrogens, can increase a person's risk of breast cancer. Estrogen is listed as a known carcinogen on the fda web site & there is a class action lawsuit ongoing against premarin (conjugated estrogens). See site: http://m.Cancer.Org/cancer/cancercauses/othercarcinogens/generalinformationaboutcarcinogens/known-and-probable-human-carcinogens. Read more...
Very likely. There is considerabel evidence that estrogens(female hormone) plays an important role in genesis of breast cancer. This was best shown in women who took hormone replacement therapy(hrt) after menopause. So such therapy(hrt) is now discouraged whenever possible. Read more...

How will I know breast cancer hormone therapy is working?

Depends on situation. If you are receiving hormonal therapy for metastatic breast cancer you will hopefully notice improvement in symptoms from the cancer or by seeing an improvement on another scan. If you are taking hormonal therapy to minimize the chance of recurrence, there is no way to know how well it is working for you as an individual. However, many studies prove that it decreases the chance of recurrence. Read more...
Hormones. May be given to treat overt measurable disease, in er++ tumors, and if you had symptomss or tests showing disease, these willl iimprove.. Adjuvant use is commonly giveen ffor 5 years....Surviving disease free is proof. Read more...

Hormone therapy for menopausal symptoms cause breast cancer?

NO BUT INCREASE RISK. Hormone therapy does not cause breast cancer but it does increase your risk of breast cancer. According to the national nurses health study using hormone replacement therapy for 10-15 yrs increases risk about 20%, if used more than 15 yrs it doubles to around 40%. Talk to your doctor to help you decide how to better manage postmenopausal symptoms. Read more...

Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?

Need to know. Er/pr receptor status on resected tumor, as if these are negative, no role for hormone therapy. Post orpre-menopausal er+ patients are treated with the effective, cheap, low adverse effect tamoxifen, a useful drug for more than 30 years. But ovarain function precluses use of anastrazome or the newer more expensive letrozole. These all work; toxiicty and cost vary. Read more...
Hormonal treatment. In general, tamoxifen is used for premenopausal women and aromatase inhibitors are used for postmenopausal women. Read more...
Estrogen supression. In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. Read more...

Does hormone replacement therapy increase your chances for breast cancer expotentionally?

Not exponentially. Data from the whi (women's health initiative) study show that estrogen alone does not significantly increase the risk of breast cancer, especially if started within 5 years of menopause. However, estrogen + Progesterone (needed when women still have a uterus to prevent uterine cancer) increases the risk of breast cancer to about 2x the baseline risk. Progesterone appears to be the "bad guy". Read more...
No. But long-term exposure is probably assocaited with a greater risk of breast cancer. But the actual risk is hard to prove and is certainly not exponential. Still, best not to take ert for more than 5 years unless you are very sympomatic from menopausal symptoms. Read more...
Absolutely Not. The whi as now reviewed was a very poor study overall and likely answers few clinical questions. I agree with the former answer that the progestin component was implicated but would not implicate Progesterone specifically. It was provera, (medroxyprogesterone) a synthetic Progesterone used in the study. The study population does not represent the typical patient we see. You need a consultation with hormone dr. Read more...

How safe is hormone replacement therapy if family history breast cancer?

Short term safety. There is no apparent increased risk for short term use of hormone therapy, with or without a family history. For longer term use (greater than 4 years) it is not clear exactly how the different estrogen and Progesterone formulations and combinations affect risk. Read more...
Varies. If a first order relative (mother, sister, daughter) has bc i would take ert only briefly and then only for severe symptoms. Remember that we try to prevent breast cancer by prescribing tamoxifen - which blocks estrogen. Adding ert definitely increases risk, somewhat, so you have to balance risks/benefits. Some women are miserable without it - and a short course may be appropriate for them. Read more...

Does hormone replacement therapy for menopausal symptoms cause breast cancer?

It can. The cause of breast cancer is so complex and poorly understood that it's better to talk about "associations" rather than "causes". Studies have shown that women who have used hormone replacement have a slightly higher incidence of breast cancer as compared to women that have not. In general, if you can avoid it, it's better to, especially if you have other risk factors for breast cancer. Read more...
In short, no. There are three human esrogens: Estradiol (from the ovary), estriol (from the placenta in pregnancy) and estrone (from peripheral fat conversion). Estrone is probably the culprit since women with excess peripheral body fat have increase rates of estrogen related cancers (breast, uterus, ovary, colon). Many oral estrogen hormones on the market are converted to estrone in the liver. Read more...
Increases risk. Hormone replacement therapy (hrt) has been shown to increase one's risk for breast cancer if taken for longer than 5 years. The current recommendation is to take low doses for a limited amount of time and then stop. There are some other non hormonal medications that can be used to help manage menopausal symptoms. Read more...
Depends. Virtually all of the studies showing that hrt increases breast cancer have been done on premarin (conjugated estrogens). Premarin (conjugated estrogens) is converted to estrone in the liver when taken orally. Overweight women convert adrenal hormones into estrone in peripheral body fat & have increased rates of estrogen dependent cancers (breast, colon, uterine). I suspect the culprit is estrone, not estradiol/estriol, the other human estrogens. Read more...