Yes. In fact, the risk of breast cancer increases with each passing year.
Yes. Incidence rates rise sharply with age until about the age of 45 to 50 when the rise is less steep. At age 75 to 80, the incidence rate flattens and decreases only slightly thereafter.
Great Question! . ..Unfortunately, not so great answer. We know that breast cancer incidence increases with age but we don't know why. We believe that cancer occurs when a cell is unable to correct a defect in its dna--perhaps this ability is diminished as we age, or the long-term effects of the "toxins" that contribute to breast cancer development are cumulative in nature.
Au Contraire! Chemistry is a foreign language too, worse when used in drugs. This cmpd has an additional -oh group on the steroid rings, so cleave it an you get Estradiol - pure estrogen. Contraindicated in people with er + tumors, i.E makes tumors grow. It is proposed as an alternative to prempro (conjugated estrogens and medroxyprogesterone) for thos with severe hot flashes, and not at high risk for breast cancer.
It may. There are three main types of estrogen, estriol is the weakest of the three and there are reports that it is protective for breast cancer. It is the breakdown products of the other estrogens (estradiol, estrone) that can increase the risk of cancer. These metabolites can sometimes be affected in a positve way by diet (eg, brocolli).
Anti-estrogen drugs. Anti-estrogen drugs are given to both premenopausal and postmenopausal women whose cancer is estrogen receptor-positive or progesterone receptor-positive. These cancer may grow when exposed to estrogen. Anti-estrogen medications block or reduce estrogen that is normally produced by the ovaries in premenopausal women or by fat cells, liver, adrenal glands or other organs in postmenopausal women.
Astute question!! Post menopausal women and women who had their ovaries removed still produce sex steroids in the adrenal glands that are later converted to estrogen. Cancer cells learn how to function with those minute quantities of Estrogens and for that reason we target the estrogen receptor pathway in these women. Thank you for that good question.
Is there a generally recommended age for a post menopausal woman, with no family history of breast cancer, to stop hrt?
Http. Usually 5 years.
Depends on symptoms. There is no recommended age. The american colllege of ob-gyn recommends using HRT as short of a time as needed to control symptoms. This will be different for every woman. A recent study came out showing that the average length if time from menopause onset to the end of hot flushes is about 10 years, but again there is much variance between people.
Yes. The current recommendations are to stop hormone replacement therapy in 5 years, depending on symptoms and circumstances.
I am a 55 year old, post menopausal woman. My ER and pr are positive and her2 is negative. I have been diagnosed with stage t1n0m0 breast cancer, my tumor being 1.2 CM big. Can chemo be avoided?
Yes. Small stage one breast cancer - your prognosis is very good. Keep in touch with your surgeon and oncologist and you should do well.
The T-1-c. Stage means it is bigger than some. Clear indication for anti-hormone (tamoxifen/anastrazole). I might consider oncotype testing tissue to discern benefit from chemo, but if you would not take it regardless of results, don't waste your money.
Need Oncotype-Dx. While your prognosis is excellent, we know that some women with your stage may benefit from traditional chemotherapy in addition to an aromatase inhibitor. Nowadays, we are moving towards molecular staging over anatomic staging; oncotype-dx is a multi-gene assay that can provide information regarding your probability of recurrence; if it is high, traditional chemo will be recommended.
Possibly. I would recommend discussing this in detail with your medical oncologist. Being a stage one it is unlikely that chemo will be required as long as the tumor has been adequately removed surgically. Stage one breast cancer is a potentially very curable stage with the proper treatment.
I would not risk it. Harmony menopause has not been shown to help with breast cancer. Many herbal supplements can interfere with cancer screening, and some can make cancer worse.
Indirectly. The incidence of breast cancer increases with age; therefore, women have a higher risk of breast cancer after menopause. However, the physiologic changes associated with menopause do not directly cause breast cancer.
Likely. Breast cancer risks increase with older age or post-menopausal state.
Not exactly. The incidence of breast cancer increases with age, so more people do get breast cancer after menopause. However, women who undergo menopause at an early age may actually have a slightly lower risk of breast cancer due to the decreased estrogen exposure.