There is not one. Remember that "supplements" have no definitive or proven real effect in the body. There are a miriad of substances that claim reverse aging: antioxidants like vitamins e, c, a. Some claims of the seed of apricot, vital procolageno , hyaluronic acid, collagen. Retinoids. And many more. Definitively smoking causes more wrinkles and premature death.
Reverse aging. A good healthy dose of enjoying your current age because no matter what you do, or what you take you will be a year older next year.
Can't reverse. "nobody grows old merely by living a number of years. We grow old by deserting our ideals. Years may wrinkle the skin, but to give up enthusiasm wrinkles the soul." ~samuel ullman with that said, i'm a huge believer in omega-3!