How exactly does progeria cause heart disease?

Abnormal metabolism. The accelerated aging syndrome known as progeria truly accelerates the patients aging and illness profile.Their metabolism is marked by the same abnormalities in cholesterol and fat metabolism in childhood as that seen in adult stroke and heart attack victims.Most succumb to complications of coronary heart disease as early as their teens.
Abnormal protein. Progeria is still being researched, but it is thought that there is a mutation in the lmna gene, which is responsible for making a protein called lamin a. An abnormal protein is produced instead, called progerin. Even normal people have a small amount of progerin, which increases as they age. Progerin affects the smooth muscles of the arteries, causing atherosclerosis and heart disease.

Related Questions

Does progeria cause heart disease?

Abnormal metabolism. The accelerated aging syndrome known as progeria truly accelerates the patients aging and illness profile.Their metabolism is marked by the same abnormalities in cholesterol and fat metabolism in childhood as that seen in adult stroke and heart attack victims.Most succumb to complications of coronary heart disease as early as their teens. Read more...

How can progeria cause heart disease?

Unknown... Children with progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease. As with any person suffering from heart disease, the common events for progeria children are strokes, high blood pressure, angina, enlarged heart, and heart failure, all conditions associated with aging. Read more...

What exactly is heart disease and why is it the leading cause of death in America?

CAD plus. Heart disease is a broad category of any condition that affects the heart. The most common condition and the condition that is the leading cause of death is coronary artery disease. This is a condition in which the blood vessels on the surface of the heart which bring blood to the heart muscle develop blockages. When these coronary arteries become blocked the result can be a heart attack. Read more...
See below. Heart disease includes: coronary artery disease,congenital heart disease, congestive heart failure, cardiac rhythm abnormalities, etc. More than half of heart deaths are due to coronary artery disease(CAD). Factors contributing to CAD:family history,smoking,obesity,cholesterol, high BP, diabetes,lack of exercise, the typical American diet. A plant based diet protects against developing CAD. Read more...
Obesity and nicotine. Some of the most common causes of damage to the arteries of the heart (high cholesterol, high blood pressure, and diabetes), are due to obesity, which is epidemic in the U.S. at this time. Another cause, nicotine use, is also a continuing problem. There are other contributing factors to heart disease also, such as inherited tendencies and lupus, but the obesity-related factors & nicotine=answer. Read more...
Too general. Gabrielle- that is too general a question as the heart is a VERY complex organ that can be subject to multiple forms of disease. therefore, you need to focus your question on a more specific topic. Sorry I couldn't help further. Read more...

Does stress cause heart disease?

Stress. Stress over time can be a partial cause and aggravating factor of heart disease. Read more...