How does alzheimer's change the brain's functioning?

Tissue Destruction. Alzheimrs disease is characterized by destruction of brain tissue in multiple brain areas. At first this is associated with simple forgetfullness, but in late stages people have loss of sphincter control, inability to bathe, dress and feed themselves. Under the microscope, the brains of alzheimer's patients show areas of tangled nerve cells.
Slowly. Over time alzheimers causes problems with memory, word finding problems, getting lost, disorientation, insight, judgement, and problem solving. These changes occur due to cell death in areas of the brain.