10 doctors weighed in:

How are proteins related to alzheimer's?

10 doctors weighed in
Dr. Mariana Dangiolo
Internal Medicine - Geriatrics
6 doctors agree

In brief: Alzheimer's Proteins

In alzheimer's disease, two proteins are known to accumulate and build up in the brain.
One protein called amyloid ? aggregates into large disruptive ‘plaques’, while tau protein forms tangled fibres within nerve cells. This excessive acummulation of proteins in the neurons eventually lead to the memory problems and cognitive decline seen in alzheimer’s.

In brief: Alzheimer's Proteins

In alzheimer's disease, two proteins are known to accumulate and build up in the brain.
One protein called amyloid ? aggregates into large disruptive ‘plaques’, while tau protein forms tangled fibres within nerve cells. This excessive acummulation of proteins in the neurons eventually lead to the memory problems and cognitive decline seen in alzheimer’s.
Dr. Mariana Dangiolo
Dr. Mariana Dangiolo
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Dr. Jeff Seaman
Psychiatry
2 doctors agree

In brief: Misfolded + inflam +

Its a problem of misfolded proteins (AB42 and Tau+) with consequent inflammation, disruption of communication between cells, and probably abnormalities in cell maintenance.
We are learning loads just these past 5-8 years with several new abnormalities and potential therapeutic engagement points.

In brief: Misfolded + inflam +

Its a problem of misfolded proteins (AB42 and Tau+) with consequent inflammation, disruption of communication between cells, and probably abnormalities in cell maintenance.
We are learning loads just these past 5-8 years with several new abnormalities and potential therapeutic engagement points.
Dr. Jeff Seaman
Dr. Jeff Seaman
Thank
Dr. Horacio Capote
Psychiatry
1 doctor agrees

In brief: By-products?

Amyloid accumulates in neurons to become the plaques that are the tell tale sign of alzheimer's disease under the microscope.
Although a fair amount of focus has been placed on these proteins, they are likely the by product of a process that we are trying to understand better.

In brief: By-products?

Amyloid accumulates in neurons to become the plaques that are the tell tale sign of alzheimer's disease under the microscope.
Although a fair amount of focus has been placed on these proteins, they are likely the by product of a process that we are trying to understand better.
Dr. Horacio Capote
Dr. Horacio Capote
Thank
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