Alzheimer's Proteins. In alzheimer's disease, two proteins are known to accumulate and build up in the brain. One protein called amyloid ? aggregates into large disruptive ‘plaques’, while tau protein forms tangled fibres within nerve cells. This excessive acummulation of proteins in the neurons eventually lead to the memory problems and cognitive decline seen in alzheimer’s.
Misfolded + inflam +. Its a problem of misfolded proteins (AB42 and Tau+) with consequent inflammation, disruption of communication between cells, and probably abnormalities in cell maintenance. We are learning loads just these past 5-8 years with several new abnormalities and potential therapeutic engagement points.