How can chronic myelogenous leukemia cause hepatomegaly?

Infiltration. The speen does enlarge in this disease. The causes include direct inflitration. Another is production of other blood elements (extramedullary hematopoesis) in the speen in response to either replacement of the marrow with CML or scar. The scarring is called myelofibrosis.

Related Questions

What happens genetically that causes chronic myelogenous leukemia?

Translocation. A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme. Read more...
See below. CML is a type of leukemia caused by a genetic abnormalty, namely a translocation between chromosomes 9 and 22 resulting in the philadelphia chromosome. This leads to a fusion of two genes, bcr ; abl, and the fusion product stimulates the proliferation of myeloid cells uncontrolably. However, the exact cause of the translocation itself is uncertain. Read more...

Can chronic myelogenous leukemia (bcr/abl) have any effect on cellular metabolism?

Why this question??? Unless you are doing some research yourself, this question has zero relevance for your/anyone's treatment for cml. So let us keep life simple and straightforward and not complicate it for all of us who are trying to help patients in desperate need for quick and simple guidance! Read more...

Can chronic myelogenous leukemia affect cellular metabolism?

It is Complex! Why is it so important to know the answer to this question for your practical purpose and guidance, it does not. But if you want to conduct research on this matter be my guest! Read more...

What are different ways to treat chronic myelogenous leukemia?

CML. CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case. Read more...
Medications. The initial treatment for CML is with oral medications called tyrosine kinase inhibitors. For recurrent disease, other chemotherapy drugs or a stem cell transplant may be used. Read more...

What's the type of inheritance of chronic myelogenous leukemia (cml)?

Not inherited. CML is associated with chromosome damage (the philadelphia chromosome). This is not inherited. The damage is to bone morrow stem cells and occurs long after birth. So the disease is not passed on to children. Read more...

What is the definition or description of: Chronic myelogenous leukemia?

CML. there are two types of CML ,juvenile and adult . each manifests marked clinical , hematological,and cytogenetic differences. Read more...

How should I treat chronic myelogenous leukemia?

CML. CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case. Read more...
By oncologist. This is a somewhat indolent form of leukemia which responds to treatment and can be carried for many years without major illenss. You could only have known about this if you had a bone marrow and blood test from your oncologist whose recommendations i would continue to follow. Read more...
See below... First of all, the treatment for any type of leukemia should be coordinated by a hematologist/oncologist. To answer your question, chemotherapy is usually necessary like for any other type of leukemia; however, there is also a special drug that is central in the chronic treatment of cml, namely Gleevec (imatinib), with a specific benefit in this type of leukemia. Read more...