What are the risk factors that lead to muscle damage?

Use or non-use. Over use and non-use cause muscle damage. Diabetes, alcohol, nutritional deficiencies, and some inflammatory disorders cause muscle damage. Statin drugs are lately a common cause of muscle damage.
MUSCLE DAMAGE. Muscles can be damaged by inflammation, infection, trauma, metabolic disorders or hereditary enzymatic defects. Muscle damage manifested as muscle weakness which leads later on to muscle atrophy.