5 doctors weighed in:

Which neurotransmitters are possibly affected by huntington's disease?

5 doctors weighed in
3 doctors agree

In brief: Acetylcholine/GABA

There are specific decreases in acetylcholine and gaba, which in turn affect the activity of the neurotransmitter dopamine.
Interestingly, this is the exact opposite of parkinson disease.

In brief: Acetylcholine/GABA

There are specific decreases in acetylcholine and gaba, which in turn affect the activity of the neurotransmitter dopamine.
Interestingly, this is the exact opposite of parkinson disease.
Dr. Lester Thompson
Dr. Lester Thompson
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In brief: Perhaps several

This autosomal dominant disorder results in a mutation of chromosome 4 producing a misfolded protein, huntingtin, which deposits in cells affecting fnctn.
Since neuroleptics work by blocking Dopamine receptors, and can help chorea, and since the striatum is involved, probably both Dopamine and glutamine are affected, at the least.

In brief: Perhaps several

This autosomal dominant disorder results in a mutation of chromosome 4 producing a misfolded protein, huntingtin, which deposits in cells affecting fnctn.
Since neuroleptics work by blocking Dopamine receptors, and can help chorea, and since the striatum is involved, probably both Dopamine and glutamine are affected, at the least.
Dr. Bennett Machanic
Dr. Bennett Machanic
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