4 doctors weighed in:

Does fabry disease affect only males?

4 doctors weighed in
Dr. Rodeen Rahbar
Surgery - Vascular
2 doctors agree

In brief: Not always

The mutation is carried on the x-chromosone.
Men have one y and one x chromosome, therefore they tend to express the gene product. Women have two x chromosomes, so it depends on which x chromosome becomes more active. In some unlucky women, they can express the full blown symptoms of fabry's disease. There are also some special cases of xy women out there, they would be likely to have symptoms.

In brief: Not always

The mutation is carried on the x-chromosone.
Men have one y and one x chromosome, therefore they tend to express the gene product. Women have two x chromosomes, so it depends on which x chromosome becomes more active. In some unlucky women, they can express the full blown symptoms of fabry's disease. There are also some special cases of xy women out there, they would be likely to have symptoms.
Dr. Rodeen Rahbar
Dr. Rodeen Rahbar
Thank
Dr. Mohammad Homsi
Neurology

In brief: Fabry disease

Fabry disease is a hereditary disease and transmitted as x-linked recessive, meaning that the carrier mother transmits the disease to 50% of her sons, in some cases females can be affected by inactivation of the other x chromosome in female patient who usually has xx, in that cases the disease may be mild comparing to severe one in the male patient.

In brief: Fabry disease

Fabry disease is a hereditary disease and transmitted as x-linked recessive, meaning that the carrier mother transmits the disease to 50% of her sons, in some cases females can be affected by inactivation of the other x chromosome in female patient who usually has xx, in that cases the disease may be mild comparing to severe one in the male patient.
Dr. Mohammad Homsi
Dr. Mohammad Homsi
Thank
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