6 doctors weighed in:
Which antiepileptic medication has the broadest spectrum?
6 doctors weighed in

Dr. Mark Fisher
Neurology
2 doctors agree
In brief: Depends
To be called broad-spectrum, an AED has to be tested against a broad spectrum of seizure types.
The major "broad-spectrum" aeds in common us use are valproic acid, lamotrigine, topiramate, levetiracetam, phenobarbital, and lacosamide. They will differ in efficacy, tolerability & side effect profile for each patient. Often, finding the right AED regimen for anyone is trial and error.

In brief: Depends
To be called broad-spectrum, an AED has to be tested against a broad spectrum of seizure types.
The major "broad-spectrum" aeds in common us use are valproic acid, lamotrigine, topiramate, levetiracetam, phenobarbital, and lacosamide. They will differ in efficacy, tolerability & side effect profile for each patient. Often, finding the right AED regimen for anyone is trial and error.
Dr. Mark Fisher
Dr. Mark Fisher
Thank
1 comment
Dr. Samuel Hunter
I would add zonisamide to that list as well.
Dr. Jeffrey Cohen
Neurology
1 doctor agrees
In brief: No clear winner
Some are more broad spectrum than others.
This category includes: valproate, levetiracetam, zonisamide, lamotrigine, and topiramate. Some of this is based on clinical experience rather than strict clinical trials. And, it does not mean that some other aeds can't cover multiple seizure types. Realize that some highly effective aeds can sometimes make some seizure types worse.

In brief: No clear winner
Some are more broad spectrum than others.
This category includes: valproate, levetiracetam, zonisamide, lamotrigine, and topiramate. Some of this is based on clinical experience rather than strict clinical trials. And, it does not mean that some other aeds can't cover multiple seizure types. Realize that some highly effective aeds can sometimes make some seizure types worse.
Dr. Jeffrey Cohen
Dr. Jeffrey Cohen
Thank
In brief: Not many
The classical broad spectrum meds include depakote, perhaps topamax, vimpat, (lacosamide) keppra.
Occasionally, Lamictal may cover the variations. Whether Lyrica should be considered this way remains to be seen. The ancient drugs such as dilantin, trileptal, Phenobarbital are not in the least, broad spectrum.

In brief: Not many
The classical broad spectrum meds include depakote, perhaps topamax, vimpat, (lacosamide) keppra.
Occasionally, Lamictal may cover the variations. Whether Lyrica should be considered this way remains to be seen. The ancient drugs such as dilantin, trileptal, Phenobarbital are not in the least, broad spectrum.
Dr. Bennett Machanic
Dr. Bennett Machanic
Thank
Get help from a real doctor now
Dr. Vicken Poochikian
Board Certified, Internal Medicine
38 years in practice
2M people helped
Continue
108,000 doctors available
Read more answers from doctors