How does hydralazine block the vagus nerve?

Not a MOA. Hydralazine is a direct smooth muscle relaxer based on its intracellular action on Calcium. In situ, it does not appear to have a direct effect on the vagus nerve, but rather may have an effect on the sinoatrial node and a reflex response (increased heart rate) due to the decreased blood pressure (baroreceptor response).

Related Questions

Does hydralazine work by blocking the vagus nerve?

Hydralazine. It relaxes vascular smooth muscles, resulting in dilation of arteries & arterioles (small vessels). Read more...