How does hydralazine block the vagus nerve?

Not a MOA. Hydralazine is a direct smooth muscle relaxer based on its intracellular action on Calcium. In situ, it does not appear to have a direct effect on the vagus nerve, but rather may have an effect on the sinoatrial node and a reflex response (increased heart rate) due to the decreased blood pressure (baroreceptor response).

Related Questions