Is Nexium (esomeprazole) the best ppi and if not, what is?

If it works for you. Nexium (esomeprazole) is one of the better studied ppis with good results in most patients. The newest ppi dexlansoprazole or Dexilant has increased efficacy and favorable bioavailability and pharmacodynamics. From my experience there is not one ppi better than others but the ppi that works the best for each individual patient. Discuss with your doctor so you may find the one for you.