9 doctors weighed in:

I am taking provigil, how does it work?

9 doctors weighed in
Dr. Peter Forster
Psychiatry
3 doctors agree

In brief: Wakes up the brain

Modafanil (provigil) appears to increase the activity of the brain wakefulness centers without causing a significant increase in Dopamine or norepinephrine release (unlike the stimulant medications).
This is why its abuse potential is lower than other medications that improve alertness.

In brief: Wakes up the brain

Modafanil (provigil) appears to increase the activity of the brain wakefulness centers without causing a significant increase in Dopamine or norepinephrine release (unlike the stimulant medications).
This is why its abuse potential is lower than other medications that improve alertness.
Dr. Peter Forster
Dr. Peter Forster
Thank
Dr. Chevies Newman
Obstetrics & Gynecology
2 doctors agree

In brief: Selective reuptake

It works almost selectively in the dorsolateral lateral frontal cortex (where u think) increasing norepi( primary signal) and dopamine( decrease background noise).
Brain cells called the tuberomammillary nucleii run from the hypothalamus to the cortex, mediated by histamine. It either activates the nucleii and the tract to stimulate the cortex or possibly so selective, feeds back and activate nucl.

In brief: Selective reuptake

It works almost selectively in the dorsolateral lateral frontal cortex (where u think) increasing norepi( primary signal) and dopamine( decrease background noise).
Brain cells called the tuberomammillary nucleii run from the hypothalamus to the cortex, mediated by histamine. It either activates the nucleii and the tract to stimulate the cortex or possibly so selective, feeds back and activate nucl.
Dr. Chevies Newman
Dr. Chevies Newman
Thank
Dr. Jerald Ratner
Psychiatry
1 doctor agrees

In brief: Stimulant

Presumably by increasing dopamine.

In brief: Stimulant

Presumably by increasing dopamine.
Dr. Jerald Ratner
Dr. Jerald Ratner
Thank
Dr. Ranji Varghese
Internal Medicine - Sleep Medicine
1 doctor agrees

In brief: Not sure

The honest answer is that we still don't really know how Provigil works.
Research suggests that Provigil actually does work by increasing the amount of Dopamine in our wakefulness centers. This is only one neurotransmitter that is involved in keeping us awake.

In brief: Not sure

The honest answer is that we still don't really know how Provigil works.
Research suggests that Provigil actually does work by increasing the amount of Dopamine in our wakefulness centers. This is only one neurotransmitter that is involved in keeping us awake.
Dr. Ranji Varghese
Dr. Ranji Varghese
Thank

In brief: Differently

It is thought Provigil was developed as an alternative to narcotic stimulants.
It works on a different set of receptors in your brain that control the release of certain chemicals, presumably to help you keep alert. The exact mechanism on neurotransmitters, like catecholamines, or various areas of the brain, are still being studied, after a look at the medical literature.

In brief: Differently

It is thought Provigil was developed as an alternative to narcotic stimulants.
It works on a different set of receptors in your brain that control the release of certain chemicals, presumably to help you keep alert. The exact mechanism on neurotransmitters, like catecholamines, or various areas of the brain, are still being studied, after a look at the medical literature.
Dr. Ibrahim Busnaina
Dr. Ibrahim Busnaina
Thank
Get help from a real doctor now
Dr. Bennett Machanic
Board Certified, Neurology
48 years in practice
55M people helped
Continue
108,000 doctors available
Read more answers from doctors