3 doctors weighed in:

Should I use neosporin, diaper rash ointment, or something else on poison oak?

3 doctors weighed in
Dr. Steven Machtinger
Internal Medicine - Allergy & Immunology
2 doctors agree

In brief: Corticosteroids

Topical antibiotics like neosporin and drying agents like diaper rash ointment - usually zinc oxide and vitamin d in petroleum jelly - offer no beneficial effects for the treatment of poison oak.
Cortiocsteroid creams are effective if the rash has not reached the blistering stage (see photo). At that point the only effective treatment is corticosteroids either orally (prednisone) or by injection.

In brief: Corticosteroids

Topical antibiotics like neosporin and drying agents like diaper rash ointment - usually zinc oxide and vitamin d in petroleum jelly - offer no beneficial effects for the treatment of poison oak.
Cortiocsteroid creams are effective if the rash has not reached the blistering stage (see photo). At that point the only effective treatment is corticosteroids either orally (prednisone) or by injection.
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