11 doctors weighed in:

How is severe combined immunodeficiency inhereited?

11 doctors weighed in
Dr. David Rosenthal
Internal Medicine - Allergy & Immunology
5 doctors agree

In brief: Forms of SCID

The original question asked about scid (severe combined immunedeficiency), not cvid (common variable immunodeficiency).
There are several types of scid. Scid can be transmitted by both x-linked, and autosomal recessive patterns. Patients with scid have a defect in their immune system that makes them vulnerable to deadly infections. See an immunologist if you suspect scid.

In brief: Forms of SCID

The original question asked about scid (severe combined immunedeficiency), not cvid (common variable immunodeficiency).
There are several types of scid. Scid can be transmitted by both x-linked, and autosomal recessive patterns. Patients with scid have a defect in their immune system that makes them vulnerable to deadly infections. See an immunologist if you suspect scid.
Dr. David Rosenthal
Dr. David Rosenthal
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Dr. Jack Mutnick
Internal Medicine - Allergy & Immunology
2 doctors agree

In brief: CVID

Also use online resources to read more and educate yourself and your family.
Go to www.Immunedeficiency.Org and the jeffrey mofell foundation to learn and read more. It really helps.

In brief: CVID

Also use online resources to read more and educate yourself and your family.
Go to www.Immunedeficiency.Org and the jeffrey mofell foundation to learn and read more. It really helps.
Dr. Jack Mutnick
Dr. Jack Mutnick
Thank
2 comments
Dr. Jack Mutnick
Please excuse the error in my spelling....I meant the Jeffrey Modell foundation.....not Mofell
Dr. Javier Chinen
Please note that the right acronym is SCID. It is usually confused with common variable immunodeficiency (CVID)
Dr. Javier Chinen
Pediatrics - Allergy & Asthma
1 doctor agrees

In brief: Two major forms

The most common form is x-linked, that can be sporadic (no inheritance), but often because the mother is a 'carrier' of the defective gene.
Only males are affected. Sons of a carrier have a 50% chance to inherit the defective gene and develop disease, daughters have 50% of inherit the defective gene and be 'carriers'. The other major form is autosomal recessive. Genetic counseling is recommended.

In brief: Two major forms

The most common form is x-linked, that can be sporadic (no inheritance), but often because the mother is a 'carrier' of the defective gene.
Only males are affected. Sons of a carrier have a 50% chance to inherit the defective gene and develop disease, daughters have 50% of inherit the defective gene and be 'carriers'. The other major form is autosomal recessive. Genetic counseling is recommended.
Dr. Javier Chinen
Dr. Javier Chinen
Thank
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