Smallpox. The WHO announced World-wide eradication of Smallpox on May 8 1980. Smallpox has no animal reservoirs. So Smallpox would not return naturally. A Smallpox patient should be isolated in a negative-pressure room until all scabs have fallen off. Provide intravenous or oral hydration wi electrolyte/ fluid monitoring. The person should be vaccinated as soon as possible after exposure. Wound care is.
Treatment supportive. Given that 30+ years have past since the last case, there may be newer meds available that would help.Treatment at the time was supportive.