It possible to build up a taste tolerance to capsaicin quickly?

Why. Capsaicin cream applied topically may help joint and muscle pain. Taking extra capsaicin orally has no proven health benefit. Capsaicin is what gives peppers their "heat." yes, the tongue can quickly adapt to eating spicy foods if that is what you mean. When applying topical capsaicin, be careful as the applying finger should be kept away from the eyes and vulvovaginal areas.