Is it safe to use ibuprofen (advil), aspirin (bayer), and acetaminophen (tylenol) at the same time?

Hard to say. You neither explain the reason for such use or the age of the patient. It is seldom a good idea to pile on OTC pain or anti-fever meds just because 1 isn't working. An office evaluation and selection of more effective agents would be the suggested plan. You wouldn't want to miss a treatable condition that would get worse while doing so.
Why? Any one of these medications is sufficient for pain relief. If you are taking low dose Aspirin for cardiac health, you may take Acetaminophen for pain relief.

Related Questions

Are aspirin, acetaminophen and ibuprofen equally good at preventing heart attacks?

No. Heart attacks are typically a result of platelets sticking together and blocking an artery in the heart. Aspirin blocks the platelets ability to stick together decreasing the chance that a blockage (heart attack) will occur. For this reason, Aspirin is one of the most effective medicines ever discovered for the prevention of heart attacks. Neither tylenol (acetaminophen) or Ibuprofen has this effect. Read more...
Only Aspirin Daily. Only Aspirin is indicated for prevention of heart attack acetaminophen and ibuprophen are not used and not recommended for prevention of heart attack. Read more...