What kind of mutation is canavan's disease?

Chromosome 17. Canavan's disease is an autosomal recessive inherited disease mapped to chromosome 17. This disorder falls into the family of leukodystrophies. This refers to a problem with myelin formation. Myelin is a key covering of the nerve sheaths. There is a specific enzyme aspartoacylase that is deficient. This is important in the pathway that leads to myelin formation. Patients have neurologic problems.