4 doctors weighed in:

Does sertraline stay in your system?

4 doctors weighed in
3 doctors agree

In brief: About a week

Sertraline half life is about one day, meaning the amount of drug in your systems drops by 1/2 each day.
So there is 50% left after day 1, 25% after day 2, 12.5% after day 3, etc. So after about a week the drug is generally out of your system. Discontinuation symptoms, like feeling "brain zaps", can last 1 - 2 weeks after stopping the medication.

In brief: About a week

Sertraline half life is about one day, meaning the amount of drug in your systems drops by 1/2 each day.
So there is 50% left after day 1, 25% after day 2, 12.5% after day 3, etc. So after about a week the drug is generally out of your system. Discontinuation symptoms, like feeling "brain zaps", can last 1 - 2 weeks after stopping the medication.
Dr. Catherine Lanteri
Dr. Catherine Lanteri
Thank
Get help from a real doctor now
Dr. Bennett Machanic
Board Certified, Neurology
49 years in practice
56M people helped
Continue
108,000 doctors available
Read more answers from doctors