How does multiple myeloma affect the kidney?

Nephropathy. Myeloma produces proteins called light chains which can essentially "clog up" the kidney producing myeloma nephropathy. Myeloma also produces humoral substances which can damage the kidney.
Myeloma and kidney. Two major causes of kidney problem in patients with myeloma - direct effect of the abnormal protein to the kidney also called myeloma kidney/cast nephropathy and increase serum calcium /hypercalcemia.. Other causes of kidney failure include amyloidosis, and drug-induced kidney damage.

Related Questions

My brother (51) is in the final stages of multiple myeloma and was told he will die of kidney failure. Blood tranfusions weekly. Timeline estimate?

Tough to say. Generally weekly transfusions are a sign that normal blood production has shut down. Blood production problems are usually a late manifestation of malignancies like myeloma. I have seen patients, for example with AML or mds, persist for many months even on weekly transfusions, so it's hard to say what a "timeline" for your brother might be. Good luck with a tough situation. Read more...
Get extra support. Agree with prior answer that difficult to say. If not already involved ask for a palliative medicine specialist to work with your hematology-oncology team. They might be able to provide additional prognostication opinions as they monitor his progress and also provide additional support for the time that he has. Read more...

Kidney biopsy shows the reason for kidney failure is multiple myeloma. No bone damage, hemo. More than 12. Will kimo therapy help to recover fully?

Seek opinion from a. This is unusual way to make a diagnosis of multiple myeloma(mm). Typically we need to do a bone marrow biopsy and look for cancer cells in the marrow. These cells produce abnormal proteins(m protein) which will show up either in the blood(commonly) or in the urine. We use a test called protein electrophoresis. If these tests have not been done, seek a second opinion. Chemo will help to control mm. Read more...

Why sickle cell anemeia / multiple myeloma cause diabetes insipidus? Is it because it may obstruct the blood flow to the kidneys and damage them?

Basically right. Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus. Read more...

How does multiple myeloma affect lung?

I am not. Aware of any direct lung issue. Mm patients are at increased risk of infection, and pneumonia is common. Some drugs can also lead to lung complications. Read more...

Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?

Need mor einfo. Myeloma has many treatment variations. Most younger patients(such as you) are treated with chemotherapy followed by bone marrow transplant(autologous type or asct)). You should discuss with your doctor the pros and cons of asct in your case. Otherwise you are doing well yet you should be on maintenance chemotherapy with a drug like lenalidomide(revlimid) at the present time. Read more...
Homeopathy, herbs ; There are no proven alternatives for multiple myeloma but that does not mean they may not help; but i would continue standard treatments too. A healthy diet, tonifying herbs, reducing body burden of heavy metals ; other environmental toxins, stress reduction ; working to clear unresolved anger/grief etc. Can only help. I also advise classical homeopathy with a good homeopath. See comments for more:. Read more...

How common is multiple myeloma?

1% . 1% of all cancers. 2nd most common hematologic malignancy. A great nci snapshot link: http://www.Cancer.Gov/aboutnci/servingpeople/snapshots/myeloma.Pdf. Read more...
Uncommon. Approximately 1% of all cancers and slightly more than 10 % of blood cancers in the United States. Read more...

What other tests for multiple myeloma?

Myeloma tests. There are many tests that are used to diagnose and stage multiple myeloma. These can include: cbc, chemistry panel, bone marrow biopsy, chromosome studies, plain xrays of the bones, 24 hour urine collection. Sometimes special imaging studies such as mri, ct or pet may be used. Read more...
Blood/Urine/Imaging. Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. Read more...