Is PMS real'?

Pms. Symptoms are real, related in part to hormonal changes during that time of menstrual cycle.
Yes. Estrogen declines at the end of the cycle creating some neurons to retract and decrease cellular communication. This coupled with the fact of impending bleeding and pain. Often, however, it is an exacerbation of underlying mood symptoms. The most prominant symptom93%, is fatigue. For pure pms, seratonin drugs for 14 days have demonstrated efficacy. Getting on an ocp sometimes helps. Good luc.