Is it bad for you to hold your urine for long periods of time because you are busy at work?

Yes. Holding and storing large volumes of urine is not healthy for the bladder. It can stretch the wall of the bladder, to which it responds by thickening. Over a long period of time, your bladder may not be able to contract efficiently and expel the urine. This is especially bad for men, because as they age, the prostate gland can obstruct the bladder making the contraction more important.