Related Questions

Will there be immunocompromise with alpha thalassemia?

Not for alpha trait. People with Alpha thalassemia trait (2 gene mutations) have no anemia or mild anemia. Their immune systems should be similar to those of non-thalassemia persons. However, for hemoglobin h disease (3 Alpha gene mutations) with more severe symptoms, their spleens may be damaged by the abnormal red blood cells. Spleen damage compromises the immune system, and certain infections would be more likely. Read more...
Not directly. Thalassemia affects red cells while immunity is related to white cells. However, with severe thalassemia, life-saving treatment may cause immunocompromise as a side effect. Read more...

What is alpha thalassemia disorder?

Hemoglobin problem. Alpha thal is caused by mutations that effect the production of a part of the hemoglobin molecule (Alpha chain). There are 4 genes involved in this production. Mutations can occur in 1 to 4 of these genes. The disease is more problematic the more genes are mutated. This disease is inherited from parents. Read more...