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What is the effect of HGH on the pituitary gland?
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In brief: Negative feedback
The pituitary gland secretes many hormones and releasing factors, including growth hormone.
Taking human growth hormone means that your internal servo control mechanism will be shut off. The pituitary cells will react as if they have made enough hormone, and so stop secreting. This may obligate you to continue replacement therapy, unless you already have a deficiency of growth hormone.

In brief: Negative feedback
The pituitary gland secretes many hormones and releasing factors, including growth hormone.
Taking human growth hormone means that your internal servo control mechanism will be shut off. The pituitary cells will react as if they have made enough hormone, and so stop secreting. This may obligate you to continue replacement therapy, unless you already have a deficiency of growth hormone.
Dr. Lester Thompson
Dr. Lester Thompson
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