2 doctors weighed in:

Why does acid cause hemolysis?

2 doctors weighed in
Dr. James Ball
Pediatrics - Hematology & Oncology

In brief: Denatures hemoglobin

In the lab, acidic solutions will denature hemoglobin, causing the red cell to hemolyze.
Fetal hemoglobin is more resistant to this. This difference is the basis of a test to determine how much fetal blood is mixed in the maternal blood system of mom's who are rh negative, and thus need rhogam.

In brief: Denatures hemoglobin

In the lab, acidic solutions will denature hemoglobin, causing the red cell to hemolyze.
Fetal hemoglobin is more resistant to this. This difference is the basis of a test to determine how much fetal blood is mixed in the maternal blood system of mom's who are rh negative, and thus need rhogam.
Dr. James Ball
Dr. James Ball
Thank
Dr. Martha Stark
Psychiatry

In brief: Can be avoided

Acetylsalicylic acid (aspirin) can cause severe hemolytic (i.
e., breakdown of red blood cells with release of hemoglobin) anemia in certain individuals who are born with a deficiency in a particular enzyme (glucose-6-phosphate-dehydrogenase -- g6pd), an enzyme needed for rbcs to function properly. Once the triggers are identified (and avoided), you can lead a healthy and active life.

In brief: Can be avoided

Acetylsalicylic acid (aspirin) can cause severe hemolytic (i.
e., breakdown of red blood cells with release of hemoglobin) anemia in certain individuals who are born with a deficiency in a particular enzyme (glucose-6-phosphate-dehydrogenase -- g6pd), an enzyme needed for rbcs to function properly. Once the triggers are identified (and avoided), you can lead a healthy and active life.
Dr. Martha Stark
Dr. Martha Stark
Thank
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