6 doctors weighed in:
What makes some hemoglobinopathies unstable?
6 doctors weighed in

Dr. Peter Kurzweil
Internal Medicine
3 doctors agree
In brief: Trait vs disease.
Hemoglobinopathies are a variety of inherited diseases where the hemoglobin molecule (part of RBC that attaches to o2 which all cells need to live) is malformed.
Examples are sickle cell & thalassemia anemia. Abnormal gene from one parent, usually have 'trait' and live healthy life. Gene from each parent, get the disease: infection, stress, a cold, other events can set off a crisis and instability.

In brief: Trait vs disease.
Hemoglobinopathies are a variety of inherited diseases where the hemoglobin molecule (part of RBC that attaches to o2 which all cells need to live) is malformed.
Examples are sickle cell & thalassemia anemia. Abnormal gene from one parent, usually have 'trait' and live healthy life. Gene from each parent, get the disease: infection, stress, a cold, other events can set off a crisis and instability.
Dr. Peter Kurzweil
Dr. Peter Kurzweil
Thank
Dr. Valentin Drezaliu
Obstetrics & Gynecology
1 doctor agrees
In brief: Hemoglobinopathies
When the structure of hemoglobin is altered due to mutation then it is more prone to earlier destruction by different mechanism. As a result the red blood cells will age and destroy much quicker than a red cell with normal hemoglobin which as a lifespan of 120 days.
It is diagnosted in early age in infant due to anemia related complications, and hemoglobin byproducts metabolism.Hope it helps.

In brief: Hemoglobinopathies
When the structure of hemoglobin is altered due to mutation then it is more prone to earlier destruction by different mechanism. As a result the red blood cells will age and destroy much quicker than a red cell with normal hemoglobin which as a lifespan of 120 days.
It is diagnosted in early age in infant due to anemia related complications, and hemoglobin byproducts metabolism.Hope it helps.
Dr. Valentin Drezaliu
Dr. Valentin Drezaliu
Thank
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