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How can chloride ions affect water transport and mucus buildup in cystic fibrosis?

2 doctors weighed in
Dr. Jay Park
Pediatrics
1 doctor agrees

In brief: Altered cell functio

Simple chemistry-water moves along with salt movement.
Fundamental defect in epithelial cell (lining cell of airway) of CF patient is an inability to secrete salt (chloride) to airway lumen and secondarily to secrete water in the presence of excessive salt and water reabsortion. The end result is dessication of respiratory secretion, and this dry thickened mucus is hard to expectorate.

In brief: Altered cell functio

Simple chemistry-water moves along with salt movement.
Fundamental defect in epithelial cell (lining cell of airway) of CF patient is an inability to secrete salt (chloride) to airway lumen and secondarily to secrete water in the presence of excessive salt and water reabsortion. The end result is dessication of respiratory secretion, and this dry thickened mucus is hard to expectorate.
Dr. Jay Park
Dr. Jay Park
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