Benign & malignant. Lymphoid hyperplasia is a normal response of the lymph nodes to infection in the local area, immunization and general infections such as epstein barr virus and cmv. The hyperplasia subsides once the stimulus is gone, e.g. Infection is under control. Lymphoma is a cancer of the lymph glands. Hyperplasia almost never leads to lymphoma, with the exception of transplant recipients.