What make creatinine levels rise?

Low kidney function. You have decreased renal (kidney) function. You should get seen by your primary doctor to find out the cause. Possible causes are: chronic high blood pressure, undiagnosed diabetes, chronic nsaid's (e.g. Ibuprofen use..), polycystic kidneys, lupus, bladder/kidney obstruction, artery blockage (stenosis) etc...
Creatinine: Kidneys. Good morning: the creatinine level rises when the kidneys are not working well. The kidneys are like a washing machine and the creatinine it the dirty laundry. When it goes up the washing machine is under some kind of stress and not fully cleaning the blood of the dirty laundry it has. It sounds like it is time to find out the cause. Please do not be afraid to ask for help.