What can be done for hemorrhoids that will not go away with medications?

Sugery. If you're suffering with hemorrhoids that haven't responded to conservative treatment, it's time to consider the next step. Surgery is a lot less painful and much more effective than it used to be!
See a surgeon. If you know you have hemorrhoids, and do not have another colon problem that may need a colonoscopy evaluation first, then a general surgeon or colon-rectal surgeon would be able to see you for an evaluation to see what options may be best for your specific condition.