5 doctors weighed in:
Is the beta-thalassemia gene recessive or dominant?
5 doctors weighed in

Dr. Robert Kwok
Pediatrics
2 doctors agree
In brief: Neither
People normally have 2 beta globulin genes.
A mutation in one or both genes leads to 3 levels of beta thalassemia. The genetics of the disorder is not all-or-none nor dominant-recessive. Instead, more or worse mutations causes worse disease. One mutation = beta thal trait (mild symptoms), 2 mutations = beta thal intermedia (transfusions sometimes) or beta thal major (lifelong transfusions needed).

In brief: Neither
People normally have 2 beta globulin genes.
A mutation in one or both genes leads to 3 levels of beta thalassemia. The genetics of the disorder is not all-or-none nor dominant-recessive. Instead, more or worse mutations causes worse disease. One mutation = beta thal trait (mild symptoms), 2 mutations = beta thal intermedia (transfusions sometimes) or beta thal major (lifelong transfusions needed).
Dr. Robert Kwok
Dr. Robert Kwok
Thank
Dr. Steven Neish
Pediatrics - Cardiology
1 doctor agrees
In brief: Recessive
Autosomal recessive typically.
Autosomal dominant inheritance has bee reported in some families.

In brief: Recessive
Autosomal recessive typically.
Autosomal dominant inheritance has bee reported in some families.
Dr. Steven Neish
Dr. Steven Neish
Thank
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