2 doctors weighed in:

Why might ldh be elevated in B12 deficiency?

2 doctors weighed in
Dr. Ibrahim Moussa
Internal Medicine - Cardiology

In brief: RBC breakdown

Ldh enzyme (subtype 4h) is very abundant in red blood cells and heart muscle.
In vit B12 deficiency there is high destruction of red cells in the bone marrow and in the blood vessels. As rbcs ruptures they release their inner content into the blood stream and this causing elevation of ldh levels in the bloodstream.

In brief: RBC breakdown

Ldh enzyme (subtype 4h) is very abundant in red blood cells and heart muscle.
In vit B12 deficiency there is high destruction of red cells in the bone marrow and in the blood vessels. As rbcs ruptures they release their inner content into the blood stream and this causing elevation of ldh levels in the bloodstream.
Dr. Ibrahim Moussa
Dr. Ibrahim Moussa
Thank
Dr. Bennett Werner
Internal Medicine - Cardiology

In brief: Non-specific

Elevation of ldh occurs in many conditions and is non-specific.
Red blood cells are little packages stuffed with ldh. Anything that interferes with the integrity of red blood cells (like B12 def) may cause them to leak some of their cargo.

In brief: Non-specific

Elevation of ldh occurs in many conditions and is non-specific.
Red blood cells are little packages stuffed with ldh. Anything that interferes with the integrity of red blood cells (like B12 def) may cause them to leak some of their cargo.
Dr. Bennett Werner
Dr. Bennett Werner
Thank
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