3 doctors weighed in:
What does sinemet (carbidopa and levodopa) consist of and what is cr?
3 doctors weighed in

Dr. Ahmad M Hadied
Orthopedic Surgery
1 doctor agrees
In brief: See below
Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.
Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.

In brief: See below
Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.
Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.
Dr. Ahmad M Hadied
Dr. Ahmad M Hadied
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2 comments
Dr. Eric Farbman
I agree with everything above. Levodopa goes to the brain and gets changed into dopamine. Carbidopa helps prevent the levodopa from going to the stomach.
Dr. William Gaya
Neurology
In brief: Parkinson's disease
Carbidopa /l-dopa; Dopamine (da) is deficient in parkinson's.
Da does not cross from blood to brain. Instead its precursor l-dopa gets into the brain and is converted into da by dopa decarboxylase (ddc) once inside the brain. Ddc is also in the bloodstream and converts ldopa to da in blood which causes nausea. Carbidopa inhibits ddc in blood, reducing nausea and allowing more ldopa in the brain.

In brief: Parkinson's disease
Carbidopa /l-dopa; Dopamine (da) is deficient in parkinson's.
Da does not cross from blood to brain. Instead its precursor l-dopa gets into the brain and is converted into da by dopa decarboxylase (ddc) once inside the brain. Ddc is also in the bloodstream and converts ldopa to da in blood which causes nausea. Carbidopa inhibits ddc in blood, reducing nausea and allowing more ldopa in the brain.
Dr. William Gaya
Dr. William Gaya
Thank
1 comment
Dr. William Gaya
CR is controlled release which allows the medication to be absorbed slowly over a longer period of time.
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