6 doctors weighed in:
Will there be immunocompromise with alpha thalassemia?
6 doctors weighed in

2 doctors agree
In brief: Not directly.
Thalassemia affects red cells while immunity is related to white cells.
However, with severe thalassemia, life-saving treatment may cause immunocompromise as a side effect.

In brief: Not directly.
Thalassemia affects red cells while immunity is related to white cells.
However, with severe thalassemia, life-saving treatment may cause immunocompromise as a side effect.
Dr. Anatoly Belilovsky
Dr. Anatoly Belilovsky
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Dr. Robert Kwok
Pediatrics
1 doctor agrees
In brief: Not for alpha trait
People with Alpha thalassemia trait (2 gene mutations) have no anemia or mild anemia.
Their immune systems should be similar to those of non-thalassemia persons. However, for hemoglobin h disease (3 Alpha gene mutations) with more severe symptoms, their spleens may be damaged by the abnormal red blood cells. Spleen damage compromises the immune system, and certain infections would be more likely.

In brief: Not for alpha trait
People with Alpha thalassemia trait (2 gene mutations) have no anemia or mild anemia.
Their immune systems should be similar to those of non-thalassemia persons. However, for hemoglobin h disease (3 Alpha gene mutations) with more severe symptoms, their spleens may be damaged by the abnormal red blood cells. Spleen damage compromises the immune system, and certain infections would be more likely.
Dr. Robert Kwok
Dr. Robert Kwok
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Dr. John Chiu
Internal Medicine - Allergy & Immunology
In brief: No
Alpha thalassemia is a blood disorder and has no effect on the immune system.

In brief: No
Alpha thalassemia is a blood disorder and has no effect on the immune system.
Dr. John Chiu
Dr. John Chiu
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