SAM-e. Taking sam-e orally can possibly improve the symptoms of depression. Several clinical studies show sam-e to be more effective than placebo, and at least as effective as tricyclic antidepressants, in trials up to 42 days. Some of these studies are limited by low #'s of patients, inconsistent diagnostic criteria, and short trial length. Dose is 400-1600mg/day -- which can become expensive.
Pretty decent. I have had multiple patients who really were opposed to SSRIs and other prescription medications use Sam-e with pretty good results. I would not recommend this for treatment of a major depression but for the blues that come with life, it is safe and effective.