4 doctors weighed in:

How can one inherit alpha thalassemia?

4 doctors weighed in
Dr. Scott Diede
Pediatrics - Hematology & Oncology
1 doctor agrees

In brief: 4 alpha genes...

It is a bit complicated given that there are 4 Alpha chain genes and Alpha thalassemia can involve mutations in one, two (in two different ways) or three genes (mutations in four genes is usually not compatible with life).
For excellent website, see: http://www.Stjude.Org/stjude/v/index.Jsp?Vgnextoid=d966885309c6f110vgnvcm1000001e0215acrcrd.

In brief: 4 alpha genes...

It is a bit complicated given that there are 4 Alpha chain genes and Alpha thalassemia can involve mutations in one, two (in two different ways) or three genes (mutations in four genes is usually not compatible with life).
For excellent website, see: http://www.Stjude.Org/stjude/v/index.Jsp?Vgnextoid=d966885309c6f110vgnvcm1000001e0215acrcrd.
Dr. Scott Diede
Dr. Scott Diede
Thank
Dr. Robert Kwok
Pediatrics
1 doctor agrees

In brief: From Mom and/or Dad

Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells.
Mom and/or dad can carry the mutations. A child can inherit a mutation from mom, from dad, or from both mom and dad.

In brief: From Mom and/or Dad

Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells.
Mom and/or dad can carry the mutations. A child can inherit a mutation from mom, from dad, or from both mom and dad.
Dr. Robert Kwok
Dr. Robert Kwok
Thank
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