Do people with alpha thalassemia trait commonly have intestinal problems?

No. People with Alpha thalassemia trait are similar to regular people. Some Alpha thal. Trait persons are mildly anemic, but the anemia is not enough to cause symptoms. A few people may be anemic enough to feel tired or have pallor (pale appearance). Intestinal problems, and other medical problems, can occur just as they occur in non-thalassemic persons.